Etiology and Prevalence

While urticaria and angioedema are common problems, affecting nearly 20% of the population, hereditary angioedema (HAE) is a rare disorder, accounting for only 2% of clinical angioedema cases. Worldwide, the incidence of HAE is approximately 1 in 30,000 to 50,000 persons.7,9

HAE affects all ethnic groups, with no recognizable racial predilection. And as an autosomal dominant inheritable genetic disorder, neither sex predominates.1


Register for updated information on HAE disease management.


In HAE, low levels of functional plasma C1-INH activate the complement, contact, fibrinolytic [glossary], and coagulation cascades. Read about the pathophysiology of HAE.

Quality of life with HAE

Patients feel depression, anxiety, and fear of unpredictable attacks, especially if they lack understanding of HAE. Read about quality of life with HAE.